College football today brings one of Week 7's biggest matchups as No. 4 Ohio State visits No. 5 Indiana on Saturday, October 17. The Buckeyes are 3.5-point favorites, but the defending national champion Hoosiers are 6-0 and riding a 22-game winning streak. Indiana also won the last meeting, beating Ohio State 13-10 in the 2025 Big Ten Championship Game. With both teams undefeated in conference play, this rematch carries plenty of weight. Our college football predictions also take a look at other ranked games, the latest odds and Saturday's best betting options.
College Football Games Today
Saturday's schedule opens at noon Eastern with No. 4 Ohio State at No. 5 Indiana and Florida at No. 7 Texas. The afternoon and evening bring more ranked matchups, including a meeting between two unbeaten teams.
Who Plays Football Today?
Wondering who plays football today? These are five of Saturday's featured games, with all times Eastern.
| Matchup | Time (Eastern) | TV |
| No. 4 Ohio State at No. 5 Indiana | Noon | FOX |
| Florida at No. 7 Texas | Noon | ABC |
| No. 6 Alabama at No. 14 Tennessee | 3:30 p.m. | ABC |
| No. 13 Missouri at No. 9 Ole Miss | 3:30 p.m. | SEC Network |
| No. 2 Notre Dame at No. 8 BYU | 7:30 p.m. | ABC |
Top NCAAF Games on Today’s Schedule
The Big Ten showdown in Bloomington leads the way. No. 2 Notre Dame at No. 8 BYU matches two undefeated teams, while No. 6 Alabama at No. 14 Tennessee puts a pair of 5-1 SEC contenders against each other.
NCAAF Preview for Today’s Top Matchups
Ohio State and Indiana bring contrasting strengths to Bloomington. The Buckeyes average 337.8 passing yards per game, while the Hoosiers rush for 221.3. Both teams can score, but neither defense has given opponents much room. The contrast could shape this Big Ten showdown.
Ranked College Football Matchups
No. 4 Ohio State wants to reverse last December's championship result against No. 5 Indiana. Elsewhere, No. 2 Notre Dame is favored by 10 points at No. 8 BYU, whose unbeaten record makes that spread worth examining.
Conference Games to Watch
Indiana, Ohio State and No. 12 UCLA are all 3-0 in Big Ten play. The SEC offers No. 13 Missouri at No. 9 Ole Miss, while No. 18 Oklahoma State travels to No. 20 Houston in the Big 12.
College Football Lines Today
The latest college football lines favor No. 4 Ohio State by 3.5 points at No. 5 Indiana. The Buckeyes are -167 on the moneyline, while the Hoosiers are +150. At this spread, Ohio State could win a close game without covering.
Point Spreads and Moneylines
Ohio State -3.5 (-108) is our featured spread. Other notable favorites include No. 6 Alabama -8.5 (-108) at No. 14 Tennessee, No. 9 Ole Miss -6 (-103) against No. 13 Missouri and No. 2 Notre Dame -10 (-108) at No. 8 BYU.
College Football Over/Under Lines
The Over 51 is priced at -103 in the game between Ohio State and Indiana, with the Under 51 at -113. The totals are 54 for Alabama-Tennessee, 61 for Missouri-Ole Miss and 47.5 for Notre Dame-BYU. In Bloomington, both defenses have allowed fewer than 14 points per game.
College Football Predictions Today
Ohio State’s passing attack gives the Buckeyes the edge in our college football predictions. They average 42.7 points per game, but Indiana allows just 188.3 passing yards per contest. Julian Sayin faces a defense that makes big gains difficult.
Predictions for Today’s Biggest Games
Predicted score: Ohio State 27, Indiana 20. Sayin has 1,772 passing yards, and Jeremiah Smith has 916 receiving yards. Indiana quarterback Josh Hoover has thrown for 1,364 yards and 17 touchdowns without an interception. Ohio State gets the nod to produce a few more big plays.
Potential Upsets to Watch
Indiana could win this game, but the Hoosiers don’t look as good as they were a season ago. The Hoosiers are 4-0 at home and won the last meeting with Ohio State. No. 8 BYU also has a chance to surprise No. 2 Notre Dame, although it enters as a 10-point underdog.
College Football Picks for Today
A projected seven-point win makes Ohio State the choice against the spread and on the moneyline. Indiana has the defense and home-field advantage to make this a tough road game, but the Buckeyes have a passing attack capable of turning a close contest in their favor.
Against-the-Spread Picks
Pick: Ohio State -3.5 (-108). The Buckeyes have won four straight and are 4-2 against the spread this season. Indiana is undefeated but has covered only once in six games. A 27-20 finish would give Ohio State a seven-point win and a spread cover.
Moneyline Picks
Pick: Ohio State -167. This bet needs only an outright Buckeyes win. We still prefer Ohio State -3.5 because our projected margin is seven points and the spread price is more attractive.
College Football Best Bets
Ohio State has scored at least 31 points in each of its four straight wins, and its passing game has carried much of that production. Indiana has been excellent defensively, but Northwestern and Nebraska both pushed the Hoosiers into close games. Containing the Buckeyes for four quarters is the challenge.
Best Bet of the Day
Ohio State -3.5 (-108) is our college football best bet. The Buckeyes have the passing game to test Indiana, and our 27-20 prediction supports the spread pick. They arrive after a 45-16 victory over Maryland.
Best Value Betting Opportunities
Under 51 (-113) is a secondary lean. Our projected score totals 47, reflecting both defenses. No. 8 BYU +10 (-108) is another option after five straight covers, although No. 2 Notre Dame is undefeated.
Key Factors Behind Today’s College Football Predictions
Ohio State averages 503.7 total yards per game, largely powered by its passing game. Indiana produces 462.7 yards per contest and has a stronger rushing average. The Buckeyes allow 96.2 rushing yards per game, making that battle central to Saturday’s college football picks.
Quarterbacks, Injuries and Team News
Sayin threw four touchdowns against Maryland and three against Iowa. Indiana receivers Charlie Becker and Nick Marsh have combined for 1,057 receiving yards and 14 touchdowns. Ohio State had four players questionable on its October 11 injury report, including two running backs. Indiana had no injuries reported at that time.
Recent Form and Home-Field Advantage
Ohio State has won four straight since falling 24-23 at Texas. Indiana beat Northwestern 29-23 and Nebraska 20-17 in two of its last three games. The Hoosiers are 4-0 at home.
Final College Football Picks and Predictions Today
The Big Ten rematch leads our college football picks for Saturday. Ohio State -3.5 (-108) is the best bet, backed by a 27-20 predicted victory over Indiana. Ohio State -167 is our moneyline selection, while Under 51 (-113) remains a secondary option for bettors who expect the defenses to hold up. Indiana's unbeaten season and home record make an upset possible, but the Buckeyes' passing attack provides the stronger case. Check the current college football lines before betting, since odds can move.
Frequently Asked Questions
Who Plays College Football Today?
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No. 4 Ohio State visits No. 5 Indiana on Saturday, October 17, at noon Eastern on FOX. Other ranked matchups include No. 6 Alabama at No. 14 Tennessee and No. 2 Notre Dame at No. 8 BYU.
Where Can I Find College Football Lines Today?
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The latest odds show Ohio State -3.5 (-108), Indiana +3.5 (-108), Ohio State -167, Indiana +150 and a total of 51. Log in for current prices because odds can change.
What Are the Best College Football Picks Today?
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Ohio State -3.5 (-108) is our best bet, with a projected 27-20 Buckeyes victory. Under 51 (-113) is a secondary lean, and No. 8 BYU +10 (-108) is another spread worth considering.
How Are College Football Predictions Made?
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Look at how teams score and defend, their recent opponents, home and road results, injuries and the current betting line. A strong prediction should explain why the expected margin supports the chosen wager.
What Should I Look for in NCAAF Expert Picks?
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Look for exact odds, relevant team statistics and a clear connection between the prediction and the bet. Good analysis explains the strengths of both teams and avoids promises about the outcome.
