MLB Odds at Prime Sportsbook: Today’s Best MLB Betting Lines and Live Odds

During the dog days of summer, you need something to bet on—and Major League Baseball delivers with a massive 2,430-game regular season. With games played daily, the MLB schedule provides consistent betting opportunities from spring through fall.

You can wager on traditional sides and totals, along with props, futures, and live betting markets. Unlike football, baseball betting is available throughout the entire week, giving bettors steady action all season long.

Let’s take a closer look at how MLB betting works at Prime Sportsbook.

How MLB Betting Odds Work

Unlike football or basketball, MLB games are not centered around large point spreads.

The most common wager in baseball is the moneyline, where you simply pick the team that will win the game outright.

Backing the favorite often requires risking more to win less, meaning bettors must maintain a higher win rate to stay profitable.

Moneyline Example

New York Yankees +105

Los Angeles Dodgers -125

A minus sign (-) indicates the favorite, while a plus sign (+) shows the underdog. If backing the Dodgers at -125, you would risk $125 to win $100. Betting the Yankees at +105 means risking $100 to win $105.

Run Line Example

New York Yankees +1.5 (-165)

Los Angeles Dodgers -1.5 (+145)

Because baseball scoring is lower, the spread is typically 1.5 runs, known as the run line.

Favorites laying -1.5 runs can return plus money, while underdogs receiving +1.5 runs require higher risk.

From first pitch to final out, understanding these markets helps bettors approach MLB wagering with confidence.

Most Popular MLB Betting Types

Before exploring specific wager options, new and experienced bettors can review our Baseball Betting Guide for a deeper look at strategies, odds formats, and how MLB markets work throughout the season.

MLB Moneylines – Pick the team that will win the game outright, regardless of score margin.

MLB Run Lines – Baseball’s version of a point spread, typically set at ±1.5 runs for each team.

MLB Totals (Over/Under) – Bet on whether the combined number of runs scored by both teams will go over or under the sportsbook’s line.

First Five Innings Betting – Focus only on the opening five innings, removing bullpen impact and emphasizing starting pitchers.

Player Props – Wagers on individual performances such as strikeouts, total bases, hits, or home runs.

MLB Parlays – Combine multiple bets into one ticket for larger potential payouts, though with increased risk. If you're new to combining selections, check out our Parlay Betting Guide to learn how odds multiply and how to manage risk.

MLB Futures – Long-term bets on outcomes like the World Series winner, MVP, or Cy Young Award.

Live Betting – Place wagers in real time as odds shift throughout the game. For strategies on timing entries, reading momentum, and managing bankroll during play, visit our Live Betting Guide.

Why Baseball Odds Change Frequently

MLB odds shift often due to key factors such as:

• Starting pitcher changes
• Lineup adjustments or injuries
• Wind direction and speed at Wrigley Field
• Bullpen usage in recent games
• Sharp betting activity

Because of these variables, baseball lines can move quickly before first pitch.

Baseball bettors who monitor these changes closely can often identify where the market is moving and why. Tracking early shifts versus closing numbers can help uncover value, especially when pitching news or sharp action drives sudden adjustments. For a deeper look at how to interpret these shifts and use them strategically, explore our Line Movement Tracking Guide.

Bet on Major MLB Events at Prime Sportsbook

Prime Sportsbook offers wagering across the biggest MLB moments, including:

• Opening Day
• The full regular season
• The Wild Card round
• Division Series and League Championships
• The World Series
• The All-Star Game and Home Run Derby

MLB action begins in late March and continues through October or early November, providing months of daily betting opportunities.

MLB Opening Day

Opening Day typically falls in late March or early April.

In 2026, the season begins March 25 with the New York Yankees visiting the San Francisco Giants, followed by the remaining teams on March 27–28—marking the earliest Opening Day in league history.

MLB Regular Season

Each of the 30 teams plays 162 games, totaling 2,430 regular-season matchups.

This schedule runs from late March or early April through late September or early October.

MLB Playoffs

Twelve teams reach the postseason:

• Three division winners per league
• Three Wild Card teams per league

Top seeds receive a first-round bye, while the remaining teams compete in the Wild Card round before advancing toward the League Championships and World Series.

MLB Wild Card Games

Wild Card matchups are best-of-three series:

• 3 seed vs. No. 6 seed
• 4 seed vs. No. 5 seed

Winners advance to the Division Series.

MLB World Series

The season concludes with the American League champion vs. National League champion in a best-of-seven series—widely known as the Fall Classic.