Week 7 CFB Betting Guide: Odds & Expert Picks

We have an outstanding lineup of five best bets that come from the top matchups in the country on Saturday.

Faurot Field in Columbia, MO, will be rocking for the SEC matchup of the Missouri Tigers and Alabama Crimson Tide (Noon ET, ABC).

The Red River Shootout takes place at the Texas State Fair each year between the Oklahoma Sooners and Texas Longhorns (3:30 p.m. ET, ABC). The ticket split will be 50/50 for the fan bases in the most important game of the season for both teams.

From the Big Ten is an undefeated showdown between the defending conference champion Oregon Ducks and the upstart Indiana Hoosiers (3:30 p.m. ET, CBS).

The Nebraska Cornhuskers hit the road to face the Maryland Terrapins (3:30 p.m. ET, BTN) after each came off potentially transformative results last week.

Finally, the USC Trojans will host the Michigan Wolverines (7:30 p.m. ET, NBC) in a classic matchup of traditional brands that used to often meet in the Rose Bowl.

Notable Week 7 College Football Odds

NC State (+21.5) is an intriguing price as a quality road dog against Notre Dame, which got the money in only two of its first five games. Notre Dame’s leaky defense could leave the back door wide open.

Texas Tech (-14.5) is an interesting line against Kansas. The Red Raiders are quietly emerging as a national power under head coach Joey McGuire, who has been bequeathed a massive budget for NIL and related expenses. Kansas is a good team, but it lacks the defense to shut down the explosive Red Raider offense.

Texas A&M (-8.5) catches attention as an emerging Top 10 power in the SEC against Florida. Florida could be in a letdown spot after its big home win over Texas last week.

CFB Week 7 Predictions

Week 7 offers a buffet of strong betting angles and values.

Missouri +5.5 vs. Alabama – Saturday brings the chance for Missouri to pick up one of its biggest wins in its history. Alabama has tightened up since its Week 1 debacle at Florida State. But Missouri remains an underappreciated program with strong metrics and good betting value. The Zou could prove to be a late morning trap for the Tide, especially with Missouri coming off a bye week with extra time to prepare and add wrinkles. Mizzou rates the call in this one!

Oregon -10 vs. Indiana – The Ducks and Hoosiers are coming off bye weeks and are on a Big Ten collision course as undefeated Top 10 programs. Curt Cignetti has accomplished what no one else has been able to do at Indiana, transforming the Hoosier program. But an assignment at Autzen Stadium is likely a bridge too far. Oregon has the look of a national champion and has been bossing the cashier’s cage this season. Oregon should roll here.

Texas -3 vs. Oklahoma – The entire country and college football gambling community has turned against Texas, which makes them a potential contrarian betting value. Last week, the Longhorns suffered their second loss of the season, on the road against the Florida Gators, and Burnt Orange Nation is in full revolt. Oklahoma is undefeated, but its offense is not producing at an elite level. With all of the squares taking Oklahoma, sharps will make the unpopular lay with a beaten power. Texas is the pick.

USC -2.5 vs. Michigan – Much like Texas, USC is losing public support after its loss to Illinois. But the Trojans are coming off a bye week and should have some surprises for a Michigan team that looked lethargic in its win over Wisconsin. Motivated USC should rebound here.

Nebraska -5.5 vs. Maryland – Last week, Maryland led Washington by 20 points in the fourth quarter and was on the cusp of a breakout season. Instead, the Terps imploded and blew the chance to make a statement in a devastating loss. On the other hand, Nebraska rallied to beat Michigan State in the type of game it used to always lose. Nebraska has the momentum edge in this spot.