Week 6 College Football Betting Tips 2025

Week 6 college football odds offer fans and gamblers a strong card with potentially excellent value to be found. The SEC marquee matchup is the Texas Longhorns at Florida Gators (3:30 p.m. ET, ESPN).

Also from the SEC is the revenge matchup of the host Alabama Crimson Tide and the upstart Vanderbilt Commodores (3:30 p.m. ET, ABC).

This is not your father’s Vanderbilt or Alabama program. Alabama was shocked by a stunning loss at Vanderbilt last year, which cost them a spot in the College Football Playoff.

In the ACC, one of the great historical rivalries will renew with the red-hot matchup of the Miami-FL Hurricanes at the Florida State Seminoles (7:30 p.m. ET, ABC).

As was the case in the 1980s, The U and FSU are emerging national powers and peaking for a power-packed showdown.

Following a week off, the Nebraska Cornhuskers will try to get back on track with a home game against the Michigan State Spartans (4 p.m. ET, FS1).

Nebraska was exposed as not yet ready for prime time in a home loss to Michigan. But star quarterback Dylan Raiola vows big things are coming.

While Michigan State is also coming off a bye week that followed a loss at USC.

Notable CFB Week 6 Odds

Michigan (-16.5) is an intriguing price at home against a Wisconsin team that has lost its identity and ability to compete at the highest level.

Ohio State (-23.5) is an interesting line at home against the Minnesota Golden Gophers. The Buckeyes scored an impressive win at Washington last week while the Gophers plodded to a home win over Rutgers.

Iowa State (-1.5) catches attention for their game at Cincinnati, in what is arguably the best Big 12 matchup of the weekend. Iowa State ran Arizona off the field last week, while Cincinnati garnered respect for a comeback win at Kansas.

CFB Week 6 Predictions

Week 6 is an opportunity for gamblers to catch some strong situational matchups.

Nebraska -10.5 vs. Michigan State – Nebraska is coming off a bye week that followed a disappointing home loss to Michigan. The Cornhuskers get a shot at redemption against a team that they match up well against. Big Red head coach Matt Rhule believes the Huskers are better than they showed. Dylan Raiola and home field should give the Big Red the edge. Nebraska should seize this redemption opportunity and cover.

Florida +7 vs. Texas – Florida has its share of issues under head coach Billy Napier, but this could be a good spot for the Gators. Texas enters the swamp as one of the most disappointing teams in college football. That is because quarterback Arch Manning has not lived up to the hype. Manning has been no more than above average. The Longhorns lack the dynamic look they had last year with Quinn Ewers under center and will be overpriced in this spot. Florida is a live dog with chomp in this matchup against an overrated big brand program.

Vanderbilt +14 at Alabama – Last year, Vanderbilt beat visiting Alabama in one of the biggest upsets of the year. Vanderbilt students carried the goal posts all the way down the strip in Nashville to celebrate. This year, Alabama is being touted for the revenge angle. However, Vanderbilt is even better in 2025 and will receive enhanced value at the betting window. Vanderbilt is the pick. This could be a letdown spot for the Tide after their big win at Georgia last Saturday night.

TCU -14.5 vs. Colorado – This game kicks off at 7:30 p.m. ET on Saturday with television coverage on FOX. The first two years of Colorado football under Deion Sanders offered some hope and a bowl berth with the dynamic combination of Shedeur Sanders and Travis Hunter. But those days are over. Now, Coach Prime is recovering from a bout with cancer and a roster that is outclassed by almost every team it faces. TCU is back in College Football Playoff form under head coach Sonny Dykes and looking dominant. TCU to roll in this one. TCU will be motivated to atone for last week’s loss at Arizona State. At the same time, Colorado struggled to find its footing last week in a home loss to BYU.