USC at Oregon: Odds, Picks & Predictions

Former Pac-12 rivals hook up for the first time as members of the Big Ten when the USC Trojans travel to Eugene for a crucial matchup with the Oregon Ducks. Oregon takes a 3-game winning streak in the series into this contest that could determine the playoff fate of each club. The game is set for Saturday, November 22 at 3:30 p.m. ET from Autzen Stadium in Eugene, OR and will air on CBS.

USC at Oregon Preview

The Trojans still have an outside chance at reaching the CFP, but another loss will derail those plans. They were in a similar position last week and fell behind Iowa 21-7 in the second quarter. Not known for their defense the past several years, USC came up large blanking the Hawkeyes in the second half allowing the offense to mount a comeback for the 26-21 win.

USC won its third straight improving to 8-2 overall. And they pulled off a rare feat; a comeback win over a quality opponent. USC was a 6.5-point favorite in college football odds but failed to cover for the second time in three games. They are 1-3 ATS in their four games this season.

Led by Jordan Maiava the Trojans are among the top 10 nationally in pass offense and total offense. Maiava leads the Big Ten and is 10th in the country with 2,868 passing yards.
USC has scored more than 30 points in a game 7 times and ranks 10th nationally averaging 38.2 points per game.
In their two losses the Trojans allowed a season-high 34 points to Notre Dame and Illinois.
USC has been able to extend drives by converting 51.7 percent of their third down plays, 8th best in the country.

The Ducks have been one of the best teams in college football, proving that fact in last week’s win over Minnesota. Playing on a short week following a trip to Iowa, Oregon easily handled the Gophers, 42-13, covering the 27-point spread. Dante Moore had a game completing 27 of 30 passes for 306 yards and 2 TDs. He totaled 198 passing yards in his previous two starts.

Defense has been a staple for the Ducks in 2025 with the group ranked among the top 5 nationally against the pass and in scoring defense. They’ve allowed fewer than 20 points in a game eight times with the UNDER 3-1 in their last four home games.

Playing without two of their top pass catchers against Minnesota the Ducks still produced 331 yards through the air and 510 total yards.
The Ducks boast the country’s best pass defense allowing just 127.3 yards a game and 5.1 yards per attempt.
Oregon’s only loss came at home in Week 7 to unbeaten Indiana, 30-20.
The Ducks are 132nd in red zone defense allowing points on 94.4 percent of drives. Opponents have had just 18 trips inside the 20, second fewest in the FBS.

USC at Oregon Predictions

Both teams are explosive on offense, but they also have underrated defenses. That holds true especially for USC, which has rarely been good on that side of the ball under Lincoln Riley. Both will attempt to limit possessions by the opponent leading to plenty of rush attempts and a final score that falls UNDER the total.

USC at Oregon Betting Tips

Early college football betting odds have Oregon at -10 and -345 on the moneyline.
The Ducks have won 18 in a row and are 11-7 ATS when playing as a double-digit favorite at home.
USC is +289 on the moneyline and 1-3 ATS in its four road games
The total hit the board at 59.
The UNDER is 4-1 in USC’s last five games and 3-1 in Oregon’s last four home contests.

USC at Oregon Head to Head and Key Stats

The teams have a long history dating back to their days in the Pac-12 having met 63 times previously with USC winning 38 games.
Oregon has had the better of the series lately winning three straight and five of the last six matchups while going 4-2 ATS.
USC’s last win at Oregon was during the 2011 season, 38-35, as a 16.5-point underdog.
The total of 59 is the lowest in the last nine games between the teams.
The teams played UNDER the closing total in two straight and three of the last four outings.