Top NFL Week 10 Picks, Parlays & Expert Betting Tips

Week 10 of the NFL season delivers international action and primetime intrigue.

Thursday Night Football opens in Denver, where the Broncos host the Raiders in an AFC West rivalry on Prime Video. Sunday morning shifts to Berlin, Germany, as the Falcons face the Colts in a neutral-site showcase on NFL Network.

The early window features Josh Allen and the Bills visiting the Dolphins in a key AFC East clash, while Lamar Jackson leads the Ravens into Minnesota to face the Vikings.

Sunday Night Football has the Steelers traveling west to meet the Chargers on NBC, and Monday Night Football wraps the week with the Eagles visiting the Packers at Lambeau Field on ABC and ESPN.

Four teams are on bye: Bengals, Chiefs, Cowboys, and Titans.

Notable NFL Week 10 Odds

● Raiders at Broncos (-9, 42.5) – Denver is nearly a double-digit favorite at home in a low-total divisional matchup.
● Falcons vs. Colts (-6, 48, Berlin) – Indianapolis is favored overseas, with one of the higher totals on the board.
● Bills (-10) at Dolphins (50) – Buffalo is the week’s largest favorite, and this matchup carries the highest total.
● Patriots at Buccaneers (-3, 48) – Tampa Bay is a slight home favorite in a matchup between two of the top teams in the league.
● Rams (-4) at 49ers (49) – Los Angeles is favored on the road in a high-total NFC West divisional matchup.
● Steelers at Chargers (-3, 45) – Los Angeles is a slight home favorite in the Sunday night game.
● Eagles at Packers (-2.5, 45.5) – Green Bay is a slight home favorite on Monday night at Lambeau.

Week 10 Betting Snapshot

● Biggest favorite: Bills -10 (vs. Dolphins)
● Tightest spread: Texans -1.5 (vs. Jaguars)
● Highest total: Bills-Dolphins 50
● Lowest total: Browns-Jets 37

NFL Week 10 Best Bets

I am coming off a fantastic week as the public was battered last week, meaning I went a perfect 6-0 against the NFL betting pointspread with the predictions, as the Titans, Falcons and Raiders covered, while the Vikings, Steelers and Cardinals not only covered, but won outright.

As a reminder, when it comes to NFL best bets each week you should know that I go against the grain with almost all of my picks. If the public does well, then I will probably struggle, but if the public loses, then I will probably have a good week.

Let’s look at Week 10 NFL predictions and let me say that I am already leery because following up a perfect week is never easy to do.

● Las Vegas Raiders +9 at Denver Broncos
The public is backing the Broncos in this Thursday night game but this is a rivalry game and the Raiders covered for us last week. I will go against the public and take Las Vegas plus the points.

● Atlanta Falcons +6 vs. Indianapolis Colts
The public is still on the Colts this week but we went against the Colts last week and it worked and we are going against them again this week with Atlanta.

● New Orleans Saints +6 at Carolina Panthers
I like what the Panthers have done so far this season, but are they really a worthy favorite? The public thinks they are so that means we take the Saints plus the points.

● New England Patriots +3 at Tampa Bay Buccaneers
I don’t know why the public is involved in this game at all, but they are backing the Bucs, so we take the Patriots plus the points.

● Arizona Cardinals +6.5 at Seattle Seahawks
The public always remembers what they saw last and it was Seattle rolling to a big win. The interesting part is that the Cardinals are also coming off a big win.

The problem with backing the Cardinals is that they might go back to Kyler Murray even though Jacoby Brissett has been better. We go against the public and take the Cardinals with trepidation if Murray starts.

● Washington Commanders +9.5 vs. Detroit Lions
I understand why the public is on the Lions as Detroit is coming off a loss and Washington doesn’t have Daniels. Maybe the Commanders will rally around Mariota this week and play well. We’ll take the big points with Washington.

NFL Week 10 Parlays

The parlays are really just a bonus section and if they come through it is just some extra money. The first week had a winner but last week both parlays were losers. I’ll keep it small with the NFL Week 10 parlays and try to hit one of the two.

● Dolphins +10 vs. Bills and Jaguars +1.5 at Texans
These two games could have easily been in the best bets section, as the public is all over the Bills and Texans. We’ll go against the public and take the Dolphins and Jaguars.

● Giants +4 at Bears and Vikings +4 vs. Ravens
Two more teams that the public likes this week are the Bears and Ravens. We’ll take the points with the Giants and the Vikings in this two-team NFL parlay.