SF 49ers at Los Angeles Rams Betting Guide

After injuries ruined their 2024 season, the San Francisco 49ers were written off for dead by many gamblers and commentators in the 2025 future market.

But after a 3-0 start, the 49ers caught the eyes of fans and gamblers as a team that could be on the path back to the Super Bowl.

Last week, the 49ers suffered a disappointing loss to the Jacksonville Jaguars.

The defeat was San Francisco’s first of the year.

This week, the 49ers hit the road for an NFC West showdown against their arch-rival Los Angeles Rams.

The Rams are coming off a quality home win over the then-undefeated Indianapolis Colts.

49ers at Rams Preview

SoFi Stadium in Inglewood, CA, is the venue for the Thursday, October 2, 2025, NFC West matchup between the Los Angeles Rams and visiting San Francisco 49ers. Kickoff time is 8:15 p.m. ET with television coverage on Prime Video.

Public Betting Odds Factors

• The 49ers remain a respected brand with the casual sector for their long-term success.

• The failure of the 49ers in 2024 turned some gamblers away, but others quickly forgave and forgot after a strong start to the 2025 campaign.

• The Rams will draw plenty of casual sector money because they are a capable home team.

• Bargain hunters and sharps may lean with the 49ers because of the more favorable road price.

49ers at Rams Predictions

Handicapping Factors to Consider 

• Check the status of the 49ers’ starting quarterback, as it could be either Brock Purdy or Mac Jones.

• The Rams are likely going to be overpriced as the home team.

• San Francisco offers good value as a quality road dog.

• San Francisco brings a strong advantage with its defense and passing attack.

49ers at Rams Prime Best Bet: San Francisco 49ers

49ers at Rams Betting Tips

• The San Francisco 49ers opened as a 5.5-point road dog.

• The Los Angeles Rams opened as a 5.5-point home favorite.

• The Rams and 49ers opened with a total of 47.5.

• The 49ers are +210 moneyline dogs.

• The Rams are -258 moneyline favorites.

San Francisco 49ers

• The 49ers have NFL metrics of 5^th for total offense, 2^nd for passing, 29^th for rushing, 22^nd for scoring, and 29^th for fewest turnovers committed.

• The Niners rank 5^th for total defense, 6^th for points allowed, but 30^th for takeaways.

• Last game, the San Francisco 49ers lost 26-21 to the Jacksonville Jaguars as 3.5-point home favorites. The game went over the total of 46.

• The 49ers are 3-1 straight up, 2-2 against the spread, and 2-2 over the total.

Los Angeles Rams 

• The Rams have NFL metrics of 4^th for total offense, 3^rd for passing, 13^th for rushing, and 13^th for scoring.

• LA ranks 9^th for total defense and 9^th for points allowed.

• Last week, the Los Angeles Rams won 27-20 against the Indianapolis Colts as 3.5-point home favorites. The game went under the total of 50.

• Los Angeles is 3-1 straight up, 3-1 against the spread, and 2-2 over the total.

49ers at Rams Head-to-Head and Key Stats

• The 49ers have drowned gamblers with red ink in recent road games. San Francisco failed to get the money in eight of its most recent 11 road games.

• The 49ers went over the total in ten of their last 15 road tilts.

• The Rams have been a solid betting value at home.  Los Angeles has covered 12 of their last 20 home games, including four of their most recent five at SoFi Stadium.

• The Rams went under the total in 11 of their last 18 home games.

• In the series between San Francisco and Los Angeles, the 49ers covered the spread in 13 of the last 20 meetings.

• The Rams covered the four most recent games.

• Four of the last five games between the 49ers and Rams went over the total.

• In Los Angeles, the 49ers got the money in nine of their last 13 meetings with the Rams.

• The Rams covered the last two games in this series at SoFi Stadium.

• The Rams and 49ers went over the total in 11 of their last 16 games at LA.