Seattle Seahawks at Arizona Cardinals Predictions

One of the best young coaches for gamblers to keep an eye on is Mike Macdonald of the Seattle Seahawks. Macdonald does not have a great roster to work with, but he is getting the most out of what he has. One asset that Macdonald does have is quarterback Sam Darnold, whom the Minnesota Vikings foolishly let go after leading them to the 2024 NFC playoffs. This week, the Seahawks hit the road to face the Arizona Cardinals, who have an impressive head coach of their own in Jonathan Gannon. Gannon and Macdonald have their teams looking like playoff contenders. Thursday night, the Cardinals and Seahawks will clash on Prime Video.

Seahawks at Cardinals Preview

On Thursday, September 25, 2025, the Arizona Cardinals will host the Seattle Seahawks at State Farm Stadium in Glendale, AZ. Kickoff time is 8:15 p.m. ET with television coverage on Amazon Prime Video.

• The Seattle Seahawks opened as 1.5-point road dogs.

• The Arizona Cardinals 1.5-point home favorites.

• The Seahawks and Cardinals opened with a total of 43.5.

• Seattle is a +102 moneyline underdog

• Arizona is a -122 moneyline favorite.

Public Betting Odds Factors

• The Cardinals do not have a good reputation with the public, and that is reflected in the betting odds.

• Because of its inept history, Arizona is one of the least popular brands with the casual sector.

• While Seattle is not a large public brand, it carries more respect and cache than the Cardinals.

• Sharps will look hard at a quality Seattle team that is the underdog.

Seahawks at Cardinals Predictions

Handicapping Factors to Consider 

• Arizona quarterback Kyler Murray has not developed as hoped.

• Murray quarterbacks one of the worst offenses in the NFL.

• Arizona’s strength is its defense.

• The Seahawks have a balanced team that is not dominant but is solid.

• The Seahawks are quite opportunistic with a strong defense.

• Seattle rarely beats itself and plays with discipline in the style of Macdonald’s mentor, Jim Harbaugh.

• In this situation, Seattle offers more value as a team that is at least as good as Arizona and getting the better price on the road.

Seahawks at Cardinals Prime Best Bet: Seattle Seahawks 

Seahawks at Cardinals Betting Tips

Seattle Seahawks 

• Seattle has NFL metrics of 18^th for total offense, 5^th for scoring offense, and 24^th for fewest turnovers committed. In comparison, Seattle ranks 14^th in total defense, 2nd in points allowed, and 2nd in takeaways.

• Last week, the Seattle Seahawks beat the New Orleans Saints 44-13 as 7.5-point home favorites. The game went over the total of 42.

• Seattle is 2-1 straight up, 2-1 against the spread, and 2-1 over the total

Arizona Cardinals 

• Arizona has NFL metrics of 25^th for total offense, 29^th for passing, and 21^st for scoring. In turn, the Cardinals rank 22^nd for total defense, 29^th against the pass, 3^rd against the rush, and 5^th for points allowed.

• Last game, the Arizona Cardinals lost 16-15 to the San Francisco 49ers. The game went under the total of 44.5.

• Now, Arizona is 2-1 straight up, 2-1 against the spread, and 1-2 under the total.

Seahawks at Cardinals Head-to-Head and Key Stats

• In this series between the Seahawks and Cardinals, Seattle got the cash in six of the last seven meetings.

• Four of the most recent six meetings between the Cardinals and Seahawks went under the total.

• Specifically in Arizona, Seattle got the cash in three of its most recent four visits.

• Four of the last five games between the Seahawks and Cardinals at Arizona went over the total.

• Seattle has been a good value on the road. The Seahawks got the cash in five of their most recent seven away games.

• The Seahawks went over the total in four of their last five road matchups.

• The Cardinals have been a good value at home. Arizona covered the spread in five of its latest seven home games.

• The Cardinals went over the total in five of their last eight home games.