Notre Dame at Louisville Picks, Odds & Best Bets

Following a promising non-conference period, the Notre Dame Fighting Irish have faced significant challenges in league play. To show, they recently suffered a heartbreaking 100–97 loss to Virginia on January 27 and an 86–72 loss to Syracuse on January 31.

Namely, freshman Cole Certa and Braeden Shrewsberry have been central to the offensive efforts. Notably, Certa recently delivered a standout performance, scoring the most points by an Irish player against an AP-ranked opponent since 2008.

In their second season under head coach Pat Kelsey, the Louisville Cardinals have shown significant improvement, highlighted by a 96–88 victory over No. 9 Kentucky earlier this season. Also, Louisville recorded an 88–74 comeback win against SMU on January 31.

Concurrently, Louisville is in the middle of the competitive ACC, tied for 7th in the conference standings. The team has been particularly strong at home at the KFC Yum! Center, posting an 11–2 home record. Leading the team in scoring is Ryan Conwell (19.5 points per game), who has recorded 19 double-digit scoring games this season.

Notre Dame at Louisville Preview

On Wednesday, February 4, 2026, the Notre Dame Fighting Irish will visit the Louisville Cardinals at the KFC Yum! Center in Louisville, KY. Tipoff is at 7 p.m. ET, with television coverage on ESPN2.

Public Betting Odds Factors

Notre Dame continues to play without star guard Markus Burton, who has been out since early December with a broken ankle.

Louisville recently saw the return of Khani Rooths from illness, but continues to monitor several questionable rotational players.

Notre Dame at Louisville Predictions

Handicapping Factors to Consider

The absence of Markus Burton has been the defining story of Notre Dame's season. Before his injury in December, Burton was the team's primary offensive engine.

The Cardinals received a boost with the return of Khani Rooths on January 31, where he recorded a double-double (12 pts, 10 reb) in just 20 minutes.

Louisville has significant advantages in offensive firepower, rebounding, bench depth, and turnover margin.

Notre Dame at Louisville Prime Best Bet: Louisville Cardinals

Notre Dame at Louisville Betting Tips

Notre Dame Fighting Irish

Notre Dame has national metrics of 289th for scoring offense, 196^th for field goal percentage, 115th for 3-point field goal percentage, 254th for free throw percentage, and 149^th for offensive rebounding.

On defense, the Irish have national metrics of 110th for scoring defense, 152^nd for field goal percentage permitted, 91^st for 3-point field goal percentage allowed, and 34^th for defensive rebounding.

The Notre Dame Fighting Irish are 11-11 straight up, 11-11 against the spread, and 14-8 over/under the total. Late on, Notre Dame has covered one out of their last seven games.

The Irish have gone over the college basketball betting total in seven of their previous eight matchups.

Louisville Cardinals

Louisville has national metrics of 41st for scoring offense, 120^th for field goal percentage, 135^th for 3-point field goal percentage, 39th for free throw percentage, and 24^th for offensive rebounding.

On defense, the Cardinals have national metrics of 74^th for scoring defense, 32^nd for field goal percentage permitted, 175^th for 3-point field goal percentage allowed, and 148^th for defensive rebounding.

The Cardinals are 15-6 straight up, 11-10 against the spread, and 8-134 over/under the total. Late on, Louisville has covered two out of its last four games.