NFL Week 5: Commanders at Chargers Betting Guide

Head coach Jim Harbaugh is wasting no time in making the Los Angeles Chargers into one of the best teams in the AFC.

The second-year taskmaster is proving why he is known as one of the great quarterback whisperers in pro football.

Harbaugh is making Justin Herbert into one of the best quarterbacks in the NFL.

The Washington Commanders have one of the most promising signal callers in Jayden Daniels.

Last year, Daniels led the Commanders to the NFC championship game as a rookie out of LSU.

Washington head coach Dan Quinn has transformed the Commanders into a legitimate NFC contender.

Daniels is expected back after missing last week’s game due to an injury.

Commanders at Chargers Preview

The Washington Commanders and the Los Angeles Chargers will meet on Sunday, October 5, 2025, at SoFi Stadium in Inglewood, CA. Kickoff time is at 4:25 p.m. ET with television coverage on FOX.

Public Betting Odds Factors

• The Commanders remain a team that gamblers need to see more from.

• Washington was the surprise team of 2024, but gamblers want assurances at the cashier’s cage that the Commanders’ success will continue in 2025.

• The Chargers are quickly catching the attention of gamblers as a rising power that could replace the Kansas City Chiefs as the best team in the AFC West

Commanders at Chargers Predictions

Handicapping Factors to Consider 

• Washington will offer more value as a good road team, getting more points than they should.

• Washington has the offense to stay within the pointspread and threaten an upset for the straight up win.

• The strong Washington rushing attack will serve as a partner to its defense by eating up time.

• Los Angeles is overpriced because gamblers are attracted to their success, and squares always take more comfort in a quality home team.

• Jayden Daniels' expected return makes Washington a completely different team.

Commanders at Chargers Prime Best Bet: Washington Commanders

Commanders at Chargers Betting Tips

• The Washington Commanders are 2.5-point road dogs.

• The Los Angeles Chargers opened as a 2.5-point home favorite.

• The Commanders and Chargers opened with a total of 47.5.

• Washington opened as a +120 moneyline dog.

• The Chargers are -142 moneyline favorites.

Washington Commanders 

• Washington has NFL metrics of 12^th for total offense, 25^th for passing, 2^nd for rushing, 8^th for scoring, and 4^th for fewest turnovers committed.

• Washington ranks 24^th for total defense, 28^th against the pass, 13^th against the rush, 18^th for points allowed, and 25^th for takeaways.

• In their last game, the Washington Commanders lost 34-27 to the Atlanta Falcons as 2.5-point road underdogs. The game went over the total of 43.5.

• Washington is 2-2 straight up, against the spread, and over the total.

LA Chargers 

• The Chargers rank 8th in total defense, 5th in passing, 21st in rushing, 20th in scoring, and 23rd in fewest turnovers committed.

• LA ranks 3^rd for total defense, 5^th against the pass, 15^th against the rush, and 3^rd for fewest points allowed.

• Last week, the Los Angeles Chargers lost 21-18 to the New York Giants as 6-point road favorites. The game went under the total of 42.

• The Chargers are 3-1 straight up, 2-1-1 against the spread, and 1-3 under the total.

Commanders at Chargers Head-to-Head and Key Stats

• In the series between the Commanders and Chargers, Washington got the cash in only one of the last six meetings.

• The Commanders and Chargers have gone under the total in four of their most recent six meetings.

• In Los Angeles, Washington did not cover its last three visits.

• Two of those three games went under the total.

• The Chargers lost only three of their most recent 12 home games.

• The Chargers went over the total in six of their last seven home games.

• Washington has covered the spread in only two of its most recent seven road games.

• The Commanders went under the total in five of their last seven road matchups.