NFL Week 16 Betting Lines & Picks

NFL Week 16 Preview

Week 16 arrives with playoff pressure tightening across both conferences and several teams entering the weekend in must-win territory. The Thursday night matchup features the Los Angeles Rams visiting the Seattle Seahawks, a divisional game that could end up deciding the NFC West and the top seed in the conference.

Saturday brings two nationally televised games with major stakes: the Philadelphia Eagles head to Washington looking to clinch the NFC East, while Green Bay travels to Chicago in a battle for first in the NFC North.

Sunday’s slate is loaded with matchups that will shape the playoff picture. Buffalo heads to Cleveland as a double-digit favorite in NFL betting odds, while Detroit, Houston, and Baltimore all enter as home favorites in games that will impact playoff positions.

With several tight spreads at the top of the board and multiple road favorites in difficult environments, Week 16 sets up as a slate where line value may hinge on identifying which teams can handle the pressure of December football.

NFL Week 16 Schedule and Betting Lines

Day	Time	Away	Home	TV	Spread	Total
Thu	8:15 pm	Rams	Seahawks	Prime	SEA -1	44
Sat	5:00 pm	Eagles	Commanders	FOX	PHI -6.5	44.5
Sat	8:20 pm	Packers	Bears	FOX	GB -1	47
Sun	1:00 pm	Bills	Browns	CBS	BUF -10	42
Sun	1:00 pm	Chargers	Cowboys	FOX	DAL -2	50
Sun	1:00 pm	Chiefs	Titans	CBS	KC -3.5	37.5
Sun	1:00 pm	Bengals	Dolphins	CBS	CIN -1.5	50.5
Sun	1:00 pm	Jets	Saints	CBS	NO -4.5	40.5
Sun	1:00 pm	Vikings	Giants	FOX	MIN -3	44
Sun	1:00 pm	Buccaneers	Panthers	FOX	TB -3	45.5
Sun	4:05 pm	Jaguars	Broncos	FOX	DEN -3	45.5
Sun	4:05 pm	Falcons	Cardinals	FOX	ATL -2.5	48
Sun	4:25 pm	Steelers	Lions	CBS	DET -7	51.5
Sun	4:25 pm	Raiders	Texans	CBS	HOU -14.5	38
Sun	8:20 pm	Patriots	Ravens	NBC	BAL -3	48
Mon	8:15 pm	49ers	Colts	ESPN/ABC	SF -6	46.5

NFL Week 16 Betting Tips

This season of picking NFL winners has simply been amazing. It is the best season I have ever had in terms of winners and it was simply fantastic last week. I went 4-1 with the picks against the NFL betting pointspread and I also hit the four-team parlay and the four-team teaser. I seem to say this every week, as I am nervous about the great streak coming to an end, but let’s ride it out. Here are NFL Week 16 Picks.

Washington Commanders +6.5 vs. Philadelphia Eagles

The public is backing the Eagles this week but the Commanders are still playing hard and they are getting a decent number of points at home. I’ll go against the public and take Washington.

Las Vegas Raiders +14.5 at Houston Texans

This one is simply ugly. The public is taking the Texans and going against the Raiders and I totally understand. The Raiders are terrible and Houston’s defense is superb. I don’t like it, but going against the public works, so I will take the Raiders plus the big points.

Indianapolis Colts +6.5 vs. San Francisco 49ers

The public is taking the 49ers on Monday night. The Colts did play well last week and they are definitely capable of keeping this one close. I will go against the public and take the Colts.

NFL Week 16 Top Matchups

Los Angeles Rams at Seattle Seahawks

Line: SEA -1| Total: 44.5 The week opens with a divisional matchup that carries weight in the NFC playoff race. The Rams opened as a small favorite but the NFL odds have moved toward Seattle. The winner of this game will take over first place in the NFC West and be in prime position to be the top seed in the NFC when the playoffs begin.

Green Bay Packers at Chicago Bears

Line: GB -1 | Total: 47 One of the league’s oldest rivalries takes center stage on Saturday night. Green Bay and Chicago are both fighting for playoff positioning, and the tight spread reflects how evenly matched these teams have been throughout the season. Soldier Field has been a difficult environment for visiting offenses, and this matchup could have direct implications on NFC seeding heading into the final two weeks.

Pittsburgh Steelers at Detroit Lions

Line: DET -7 | Total: 51.5 Detroit returns home as one of the larger favorites of the week, hosting a Pittsburgh team that has been inconsistent on the road. The Lions remain in playoff contention and this matchup gives them an opportunity to maintain pressure on the conference leaders. Pittsburgh’s defense will need to limit Detroit’s big plays to keep this one competitive.

New England Patriots at Baltimore Ravens

Line: BAL -3 | Total: 48 Sunday night features a matchup with major AFC implications. Baltimore continues to push for a division title, while New England enters as a road underdog looking to stay alive for the top seed in the AFC. The Ravens have been strong at home, and the total suggests a game where both offenses will have opportunities to move the ball. This is one of the most meaningful primetime games of the week.