NFL Picks: Chiefs vs Giants Odds & Betting Preview
Following their blowout loss to the Philadelphia Eagles last February, the Kansas City Chiefs vowed a redemption tour and to beat the Eagles in their home opener at Arrowhead.
Instead, Kansas City lost a game that was not nearly as close as the score indicated. The Chiefs got a lot of empty calorie stats that did not translate to actual superiority on the field.
Now the Chiefs are 0-2 and facing increased doubts that age and the normal NFL betting cycles are finally catching up to them.
As time passes, it becomes increasingly apparent that the New York Giants and head coach Brian Daboll were a one-off fluke in their 2022 playoff run.
Russell Wilson is now the Giants' stop-gap quarterback, but coming off a strong 450-yard passing performance in a loss at Dallas, in which the Giants' defense failed to close the sale.
The Giants will host the Chiefs Sunday night in an NBC matchup of desperate and winless teams.
Chiefs at Giants Preview
On Sunday, September 21, 2025, the New York Giants will host the Kansas City Chiefs at MetLife Stadium in East Rutherford, NJ. Kickoff time is at 8:20 p.m. ET with television coverage on NBC.
Public Handicapping Factors
- The Chiefs are facing increased doubts at the betting window.
- Kansas City’s Super Bowl humiliation is now being seen as the landmark moment when its dynasty began to crumble.
- Travis Kelce has become a liability for the Chiefs and a perpetual distraction and drama machine. He is indicative of the Chiefs' collapse.
- Gamblers wonder how the Giants will respond to their heartbreaking overtime loss at Dallas.
Chiefs at Giants Predictions
Handicapping Factors to Consider
- Despite its numerous problems, Kansas City is a proud team and motivated to get its season on track.
- The Chiefs have more talent and a winning tradition compared to the Giants
- The Giants got a gut-punch loss at Dallas that could have turned their season around.
- Can Russell Wilson play at the same high rate that he did at Dallas?
Chiefs at Giants Prime Best Bet: Kansas City Chiefs
Chiefs at Giants Betting Tips
- The Kansas City Chiefs opened as a 5.5-point road favorite against the New York Giants, who were listed as 5.5-point home dogs.
- The Chiefs and Giants opened with a total of 44.5.
- On the moneyline, the Chiefs opened as a -250 road favorite with the Giants as a +205 home dog.
Kansas City Chiefs
- Overall, Kansas City ranks 24th for total offense and 22nd for scoring offense. By contrast, the Chiefs rank 12th for total defense and 20th for points allowed.
- Last week, the Kansas City Chiefs lost 20-17 against the Philadelphia Eagles as 1-point home dogs. The game went under the total of 47.5. As a result, Kansas City is 0-2 straight up, 0-2 against the spread, and 1-1 over the total.
New York Giants
- Overall, New York ranks 15th for total offense and 18th for scoring offense. New York ranks 25th for total defense and 28th for scoring defense.
- Last week, the New York Giants lost 40-37 as 5.5-point road dogs. The game went over the total of 44.5. Now, New York is 0-2 straight up, 1-1 against the spread, and 1-1 over the total.
Chiefs at Giants Head-to-Head and Key Stats
In the series between the Chiefs and Giants, New York covered the spread in nine of the most recent ten meetings. The series went over the total in only three of the last 11 meetings.
Specifically at MetLife Stadium, the Giants won their last five games against the Chiefs. The last three games between the Giants and Chiefs in New York went under the total.
In like manner, the Giants have struggled in recent home games with only three payouts in their last nine matchups. The Giants went under the total in 12 of their last 17 home games.
The Chiefs have experienced recent struggles on the road, with only two wins in their last eight road matchups. Kansas City went under the total in three of its last five away matchups.
