NFL Monday Night Football Predictions: Giants vs. Rams Odds

The season didn’t start the way the Super Bowl favorite Los Angeles Rams hoped. The Rams were steamrolled by division rival San Francisco in their Week 1 opener in Australia and lost prized off-season acquisition Myles Garrett in the process. Garrett was placed on IR and will miss at least four games starting with the Week 2 NFL Monday Night Football game against the New York Giants, who won their opener for the first time in four years. Despite the contrasting results the Rams opened as a 7-point favorite on the NFL betting line.

NFL Monday Night Football Game This Week

NFL football on Monday night has been a staple of the season schedule since the 1970 merger and according to broadcast analyst Troy Aikman the 2026 slate is the best MNF schedule we’ve ever had. The Rams are back home looking to pivot from a 20-point loss to the 49ers while the Giants head across the country fresh off an impressive divisional win against Dallas on Sunday Night Football. 

Monday Night Football Matchup Preview

• The Week 2 NFL Monday Night Football game between the New York Giants and Los Angeles Rams is scheduled for September 21, 2026. 
• The early season NFC showdown will kick off at 8:15 p.m. ET with television coverage on ESPN and ABC.
• The game will be played at SoFi Stadium in Inglewood, CA.

Key Storylines for This Week’s Game

• New York enters the NFL Monday Night Football game with momentum after upsetting Dallas in Week 1. The Giants are seeking their first 2-0 start since the 2022 season.
• The Super Bowl favorite Rams are looking to bounce back from a rough opening loss to San Francisco when the high-powered offense was ground to a halt.
• The Rams will have to pick it up defensively without reigning DPOY Myles Garrett. The unit had a hard time containing the Niners, allowing 5.9 yards per play and stopping just 5 of 12 third-down plays.

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Who Plays Monday Night Football NFL?

Longtime members of the league, the Week 2 NFL Monday Night Football game will mark the 48th all-time meeting between the Giants and Rams and the first since the 2023 season. The Rams carry a four-game series winning streak into the contest.

Teams Playing Monday Night Football

• This is the first of two scheduled appearances on Monday Night Football for the Giants, who will also play at Detroit in Week 16. According to StatMuse the Giants are 27-52-3 on Mondays.
• The Rams are also scheduled to make two appearances on MNF this season, hosting Buffalo in Week 5. LA is 33-39 all-time in Monday night games.

Current Records and Recent Form

• The Giants opened the John Harbaugh era in grand style knocking off NFC East rival Dallas, 28-20, last week. Dating back to last season the Giants have now won three straight games, their longest streak since the 2023 season.
• The Rams fell to 0-1 with their 27-7 setback to the Niners suffering their worst loss since Week 2 of the 2024 campaign. They finished that season 10-7 and reached the playoffs.
• The Rams have won the last four head-to-head meetings, all of them under coach Sean McVay.

NFL Monday Night Football Odds

The NFL Monday Night Football odds for the Week 2 clash between the Giants and Rams have the home team as a comfortable touchdown favorite despite the results in Week 1. Analysts expect the Rams to rebound from their disappointing showing in Australia where travel plans may have played a role in their 27-7 setback. The total is positioned at 48 points with NFL Monday Night Football predictions indicating a high scoring game.

Moneyline Odds

• New York Giants +295
• Los Angeles Rams -352

Point Spread

• New York Giants +7 (-112)
• Los Angeles Rams -7 (-104)

Game Total

• Over 48 (-116)
• Under 48 (-101)

NFL Monday Night Football Picks

We didn’t see an overreaction on the NFL Monday Night Football odds for the Week 2 contest between the Giants and Rams. Though LA was humbled in a loss to San Francisco and the Giants beat the Cowboys, the Rams are positioned as a significant 7-point favorite with most experts expecting them to recover from their rough trip to Australia.

Best Spread Pick

• With all their preseason accolades maybe the Rams needed to be brought down a peg. A 20-point loss to a division rival will do that.
• Matthew Stafford is getting long in the tooth but he still has something left and the Rams have the weapons to be among the league scoring leaders.
• Laying a touchdown is steep against a John Harbaugh team, but look for the Rams to be focused at home in a game they need, making them the NFL Monday Night Football pick.

Best Total Pick

• The Giants were efficient on offense against Dallas going 9 of 11 on third-down and averaging 5.8 yards per play. That’s something we haven’t seen in past seasons.
• Behind MVP Matthew Stafford the Rams led the NFL in scoring last season. They will make adjustments after a woeful start against the Niners.
• The total is up there at 48 and the way teams were scoring last week that feels small. Backing the OVER on the total is the smart play.

Best Moneyline Pick

• The steep price makes a straight bet on the Rams expensive, but with experts backing a definitive home win it is the best NFL Monday Night Football pick.
• The best way to use this high-confidence moneyline pick is as part of a multi-leg parlay to boost your total payout since a straight bet has little value.

NFL Monday Night Football Predictions

Most NFL Monday Night Football predictions have the Rams rebounding with a win probability of more than 75 percent. However there is some disagreement on whether New York can stay within the 7-point spread. That means you’re betting against the expectation of a big bounce back effort from a team that’s the favorite to win the Super Bowl.

Matchup Prediction

• With a few extra days off the Rams should be recovered from their trip to Australia. Back home they have the environment needed to fix their issues from Week 1.
• LA’s strong group of receivers should find soft spots against a young Giants secondary with Stafford being more in sync with his playmakers.

Score Prediction

• Throughout his tenure Sean McVay has shown the ability to make adjustments and get his team right from a loss. 
• The Giants upset Dallas last week by controlling the football with a balanced attack and converting more than 80 percent of third-down plays. They won’t do that this week allowing the Rams more chances to score.
• Backing LA for a 31-20 home win is the NFL Monday Night Football pick.

Betting Prediction

• The Rams are still elite and the Giants are rebuilding under John Harbaugh.
• NFL Monday Night Football predictions have the Rams covering the spread with the game going OVER the total.

NFL Prop Bets Monday Night Football

For primetime matchups sportsbooks go the extra yard to build an expansive prop bet menu. NFL prop bets for Monday Night Football swirl around the Rams offense, which most feel will have a breakthrough game after the debacle in Week 1. Under Sean McVay the Rams have historically responded well winning 72 percent of their games following a loss.

Quarterback Props

• Jaxson Dart had a stunning opener throwing for 230 yards and three TDs with an additional 54 yards rushing. He’s listed with an aggressive rushing line and a short anytime TD price.
• After a dismal opener where he got benched in the second half, Matthew Stafford is primed for a greater performance. His OVER 1.5 passing TDs is heavily juiced.

Running Back Props

• Cam Skattebo returned from injury and established himself as the Giants go-to short-yardage back. Target his anytime TD prop with chances at the goal line.
• Look for the Rams to establish a ground game to assist the offense with Kyren Williams as the featured player. His rushing yardage and anytime TD lines are heavily backed.

Receiver Props

• The reception and yardage props for Giants tight end Isaiah Likely have bumped after last week’s outburst. That gives value to the UNDER in those NFL prop bets.
• Puka Nacua has huge target shares in games at SoFi Stadium with at least 7 catches in 14 straight home games. Expect him to be a big part of LA’s passing game.

NFL Player Props Monday Night Football

The Rams led the NFL in scoring last season but they produced the fewest points of any team in Week 1. With the unit poised for a strong return, NFL player props for Monday Night Football are targeting a number of LA playmakers. Following the opening week trends, the betting markets offer active prop options for both the Giants and Rams 

Best Player Prop Picks

• Puka Nacua has caught at least 7 passes in 14 straight home games making him a favorable target to surpass his total of 6.5 receptions.
• If the Giants have to play catch up they will throw the football leaving Jaxson Dart exposed to going OVER his relatively low passing yard total of 213.5.

Touchdown Scorer Props

Kyren Williams knows how to find the end zone – he scored LA’s lone TD in Week 1. NFL Monday Night Football odds have Williams topping the board as the most likely player to score a touchdown. Check odds at Prime for updated numbers.

• Kyren Williams -150
• Puka Nacua +100
• Cam Skattebo +110
• Davante Adams +115
• Malik Nabers +160

Yardage and Reception Props

• Following a breakout performance against the Cowboys, Isaiah Likely has high-volume expectations against the Rams.
• Analysts favor a stronger performance by the Rams offense focusing on a passing game with Puka Nacua the main target. He has at least 7 receptions in 14 straight home games and is poised to clear his total of 6.5 catches.

Key Factors for Monday Night Football Predictions

For the Week 2 matchup between the Giants and Rams analysts point to several factors that could shape NFL Monday Night Football predictions. Travel is a big issue for both clubs while the Rams look to strengthen their defense in the absence of Myles Garrett.

Injuries and Short-Week Preparation

• The Rams are home after their trip to Australia that took a toll in the opening loss to the Niners. They had a few extra days to recover from the Thursday night debacle. The Giants have a regular schedule despite the cross-country trip.
• Myles Garrett was a non-factor in his Rams debut and was later put on IR with knee soreness. LA could counter by adding Aaron Donald to the roster. He remains a game-time decision.

Home-Field Advantage

• The Rams used their homefield advantage to win 12 games a season ago. They went 7-1 on their own turf and covered the NFL betting line seven times as a home favorite.
• While it’s technically a Rams home game, visiting fanbases have customarily taken over SoFi Stadium. With renewed enthusiasm following an upset of Dallas, the Giants could have a good amount of fans negating LA’s advantage.

Matchup Trends

• The Rams have won the last four head-to-head matchups with the teams cashing the OVER in three of those games. 
• New York has won three of the last four games when playing as the visiting team earning the payout in every game.
• The only meeting at SoFi Stadium occurred in 2020 with the Rams winning 17-9, though they failed to cover the 13-point spread.

Monday Night Football Betting Trends

Monday Night Football odds feature diverse historical patterns and situational factors that show home teams often underperform against the spread. In addition primetime point totals lean toward slightly lower scoring. Bettors handicapping these matchups also include extra recovery time and historical team success rates.

Against the Spread Trends

• Past betting data shows that home teams on Monday Night Football underperform against the NFL betting line. That wasn’t the case last week, though, when the Chiefs won and covered at home against Denver.
• Since Monday Night Football is a standalone game, public money flows to brand recognition and star players often adding value to the less popular club.

Over/Under Trends

• Primetime UNDERs – particularly in Monday Night Football games – hive historically hit at a more profitable rate early in the NFL season.
• Public bias consistently drives point totals higher than the actual game pace warrants. Last week’s MNF game finished UNDER the relatively low total of 42.5.
• Casual bettors prefer to back the OVER adding an artificial premium that creates value on backing the UNDER.

Head-to-Head Trends

• Early season NFL Monday Night Football games often feature slower offensive pace as teams work on tactics and schemes. Still, public betting often moves toward the OVER.
• The previous two meetings and three of the last four between the Giants and Rams went OVER the total.
• In the most recent meeting during the 2023 season, Matthew Stafford threw for 317 yards but was also intercepted twice in a 17-9 Rams victory.

Final Thoughts on NFL Football Monday Night Football

The biggest thing is to not overreact to Week 1 results. The Rams looked awful in their loss to the Niners scoring only seven points, that from the league’s highest scoring team a season ago. Most analysts are predicting a rebound from the Rams in this NFL Monday Night Football. LA is focused on fixing their first-game mistakes while also adapting to life without Myles Garrett. There is a chance Aaron Donald returns, solidifying the Rams front. The John Harbaugh era is off to a good start, but the Giants are still in rebuild mode after several lean years.