NFL Divisional Weekend Odds & Best Bets

Divisional Weekend Preview

The NFL divisional round opens on Saturday with two matchups shaped heavily by rest and scheduling. Denver enters as a 1-point favorite on the NFL spread over Buffalo, with early money backing the top seed against a Bills team on short rest after last Sunday’s win.

Josh Allen still gives Buffalo strong public appeal, but Denver’s bye week and altitude advantage make this one of the more volatile lines of the weekend. In the night game, Seattle is a 7-point favorite against San Francisco, reflecting both the Seahawks’ bye and the 49ers compressed turnaround from a Sunday road game.

Seattle’s dominant Week 18 win and San Francisco’s injury concerns, including George Kittle, reinforce the current number.

Sunday brings two more compelling matchups with sharper edges. New England is a field-goal favorite over Houston, with the Texans’ elite defense keeping the spread from climbing higher despite Nico Collins’ likely absence after his second concussion of the season.

The total of 41 fits Houston’s defensive profile. The weekend closes with the Rams laying 4 points on the road in Chicago, a number that balances Los Angeles’ higher power rating with the Bears’ season-long knack for tight wins. The total of 50 signals confidence in both offenses, especially the Rams’ explosive ceiling.

Super Bowl odds mirror the weekend’s hierarchy: Seattle leads at +288, followed closely by the Rams at +313, with Buffalo +530 and New England +625 topping the AFC contenders.

NFL Divisional Weekend Schedule and Betting Lines

Saturday, January 17

Time (ET) Away Home TV Spread Total

4:30 pm Buffalo Denver CBS Den -1 46.5

8:00 pm S.F. Seattle FOX Sea -7 45.5

Sunday, January 18

Time (ET) Away Home TV Spread Total

3:00 pm Houston New England ESPN NE -3 41

6:30 pm L.A. Rams Chicago NBC LA -4 50

Divisional Weekend Matchups

Bills at Broncos — Denver -1, Total 46.5 The market opened the week backing Buffalo, but early action pushed Denver to a 1-point favorite on the NFL playoff spread. Bettors leaned toward the rested No. 1 seed against a Bills team playing on short rest after last Sunday’s win. Buffalo still carries strong public appeal with Josh Allen, so late-week money could shift this number again. The Bills have been underdogs only twice this season and won both outright.

49ers at Seahawks — Seattle -7, Total 45.5 Seattle sits as a full touchdown favorite after drawing the scheduling advantage: a bye week versus San Francisco’s short turnaround from a Sunday road game in the Eastern time zone. The 49ers’ injury issues — including George Kittle — add to the challenge. Seattle’s 13-3 win over the Niners in Week 18 is reflected in the number, and a 7-point spread at home aligns with that earlier matchup.

Texans at Patriots — New England -3, Total 41 Oddsmakers landed on a full field goal for New England, installing the Patriots as -3 at home. Houston’s defensive surge — 10 straight wins — kept this from climbing higher, but Nico Collins’ likely absence after his second concussion of the season weighs on the Texans’ offense. With Houston’s defensive profile, the 41-point total sits on the higher side for their typical game script.

Rams at Bears — Los Angeles -4, Total 50 The Rams remain 4-point road favorites despite Chicago’s knack for tight wins. Los Angeles is still viewed as the stronger team, but last week’s narrow escape against Carolina and the Bears’ late-game resilience have drawn some early Chicago interest. The total at 50 reflects confidence in both offenses, especially with the Rams’ explosive ceiling.

Divisional Weekend Betting Tips

It was a fantastic regular season for the NFL picks, but the Wild Card round didn’t go well, as the public did much better last week. Let’s see if we can get a couple of winners against the NFL betting pointspread as we go against the public in the NFL Divisional round.