NFL Betting: Vikings at Lions Odds & Best Bets

The Detroit Lions remain in the thick of the NFC North race. Additionally, Detroit is in the mix for the NFC's top seed and home-field advantage in the 2025 NFL Playoffs.

However, the Lions, while profitable, will occasionally stub their toes against the NFL betting odds.

On Sunday, one of those lapses is possible against the Minnesota Vikings.

Minnesota has been struggling with quarterback injuries, but has not lost its season—at least for now.

The Vikings could give their season a boost with a win against the rival Lions.

But the trade of Sam Darnold may haunt the Vikings for a long time.

Darnold was foolishly discarded after leading Minnesota to the 2024 NFL Playoffs.

Vikings at Lions Preview

On Sunday, November 2, 2025, the Detroit Lions will host the Minnesota Vikings at Ford Field in Detroit, MI. Kickoff is at 1 p.m. ET, with television coverage on FOX.

Public Betting Odds Factors

• The Minnesota Vikings are not a team that gamblers trust.

• Still, Minnesota will draw occasional support in the right spot.

• Minnesota is one of the most inconsistent teams on the NFL board.

• Detroit is one of the most popular teams in the NFL.

• Most important of all, the Lions are in the black.

• However, Detroit consistently faces the danger of being overpriced at home.

Vikings at Lions Predictions

Handicapping Factors to Consider 

• The unstable Minnesota quarterback situation continues to be a problem.

• Detroit has a significant advantage at quarterback.

• The Lions are a proven value at Ford Field.

• Minnesota has not been a reliable betting value on the road.

• The Lions dominate the payout window at home against the Vikings.

Vikings at Lions Prime Best Bet: Detroit Lions 

Vikings at Lions Betting Tips

Detroit opened as an 8.5-point favorite and a -480 moneyline chalk.

Minnesota opened as an 8.5-point dog and a +370 moneyline dog.

The Vikings and Lions opened with a total of 47.5.

Minnesota Vikings 

• Minnesota ranks 27^th for total offense, 22^nd for passing, 26^th for rushing, 18^th for scoring, and 27^th for fewest turnovers committed.

• Minnesota ranks 10^th for total defense, 7^th vs. the pass, 23^rd vs rush, 20^th for fewest points allowed, and 24^th for takeaways.

• Last game, the Minnesota Vikings lost 37-10 against the Los Angeles Chargers as 3-point road dogs. The game went over the total of 44.5.

• Minnesota is 3-4 straight up, 3-4 against the NFL odds, and 6-1 over/under the total.

Detroit Lions 

• Overall, Detroit ranks 9^th for total offense, 13^th for passing, 5^th for rushing, 3^rd for scoring, and 6^th for fewest turnovers committed.

• Detroit ranks 8^th for total defense, 16th vs. the pass, 5^th vs. rush, 12^th for fewest points allowed, and 6^th for takeaways.

• The Lions are coming off a bye week. Previously, the Lions beat the Tampa Bay Buccaneers 24-9 as 6-point home favorites.

• The game went under the total of 54.

• Now, Detroit is 5-2 straight up, 5-2 against the spread, and 3-4 over/under the total.

Vikings at Lions Head-to-Head and Key Stats

• In the series between Minnesota and Detroit, the Lions covered the spread in nine consecutive games.

• The Lions and Vikings went over the total in eight of their last ten matchups.

• Specifically, at Detroit, the Lions are riding a 5-game winning streak vs. the odds against the Vikings.

• Five of the last six games between the Lions and Vikings in Detroit went over the total.

• The Vikings have been an unreliable value on the road.

• Minnesota got the cash in only four of its most recent ten away games.

• Minnesota went over the total in five of its last seven road tilts.

• Detroit has been a solid value at Ford Field.

• The Lions have received the cash in 11 of their most recent 17 home games.

• The Lions went over the total in 12 of their last 17 home games.