Miami Dolphins at Buffalo Bills Betting Tips

The Miami Dolphins are quickly on the brink of losing their season and what little is left of their reputation. The Dolphins are coming off losses in their first two games.

Last weekend in their home opener, the Dolphins fell to a subpar New England Patriots squad. The Dolphins are struggling to finish drives and are deep in their own territory for the turnover margin.

Miami’s problems begin at the top with hyper-sensitive head coach Mike McDaniel, who cried with players who are injured. Just as important, McDaniel has not developed a team tough enough for a championship stage.

The Buffalo Bills are quite different from the Dolphins. Buffalo emphasizes toughness and mental resiliency.

Head coach Sean McDermott is one of the most proven head coaches in the NFL. Buffalo has been a perennial contender under his leadership.

The two quarterbacks in this game are direct reflections of their head coaches. Miami’s Tua Tagovailoa is oft-injured and fails under the bright lights, while Buffalo’s Josh Allen is a swashbuckling and respected leader.

Dolphins at Bills Preview

On Thursday, September 18, 2025, the Buffalo Bills will host the Miami Dolphins with a kickoff time at 8:15 p.m. ET. Highmark Stadium, Orchard Park, NY, is the venue with television coverage on Prime Video.

Public Betting Factors

The Miami Dolphins are stock down in the minds of almost all gamblers. The Dolphin brand is one of softness and incompetence.

Gamblers will have a difficult time generating enthusiasm for taking a risk on the Dolphins.

Buffalo is the much more appealing team to gamblers, especially after the respective starts to the season by the two teams.

Dolphins at Bills Predictions

Handicapping Factors to Consider

Although Miami lacks public appeal, there is the danger that too much money will go towards the Bills at the betting window. As a result, bargain hunters will look at Miami potentially getting more points than what is warranted.

Buffalo is an easy sell to gamblers in this spot, which does open up the possibility of an overlay.

Buffalo is in much better form and will bring more confidence to the field than the Dolphins.

Of the two teams, Buffalo is more proven, stable, and successful. Miami’s poor play cannot be translated into a recommendation.

Dolphins at Bills Prime Best Bet: Buffalo Bills

Dolphins at Bills Betting Tips

The Miami Dolphins opened as a +12.5-point road dog while the Buffalo Bills are -12.5-point home favorites.

The Dolphins and Bills opened with a total of 49.5.

On the moneyline, the Dolphins opened as +550 road dogs with the Bills as -800.

Miami Dolphins

Overall, Miami ranks 5^th in total offense but 32nd in scoring and 29th in fewest turnovers committed. The Dolphins rank 31^st in total defense, 30th in fewest points allowed, and 27th in takeaways.

Last week, the Miami Dolphins lost 33-27 to the New England Patriots as 2.5-point home favorites. The game went over the total of 42.5. Miami is 0-2 straight up, 0-2 against the spread, and 1-1 over the total.

Buffalo Bills

Buffalo ranks 8^thfor total offense and 2^nd for scoring offense. In comparison, the Bills rank 6^th for total defense, 22^nd for points allowed, and 29^th for takeaways.

Last game, the Buffalo Bills won 30-10 against the New York Jets as 6-point road favorites. The game went under the total of 47.5. Buffalo is 2-0 straight up, 2-0 against the spread, 1-1 over the total.

Head-to-Head and Key Stats

In this series, Buffalo is 5-4-1 against the spread vs. Miami with only one straight-up loss in that span. Four of the most recent six games between the Bills and Dolphins went over the total.

Specifically at Buffalo, the Dolphins are 3-1-1 against the spread in their most recent five visits. Additionally, the Bills and Dolphins exceeded the total in nine of their last 10 games at Buffalo.
Miami has been a weak betting value on the road. To show, the Dolphins have covered the spread in only six of their last 17 games in that role. Miami went under the total in 12 of its most recent 18 road games.