Memphis at Louisville Betting Guide & Odds

Longtime conference rivals renew a bitter feud that’s been dormant for eight years when the Memphis Tigers take on the Louisville Cardinals. The schools competed on the hardwood in several different leagues until Louisville joined the ACC in 2014 essentially putting an end to a series that has been played 90 times.

After suffering their first loss of the season at Arkansas last week, the Cardinals regained their winning formula improving to 8-1 with a decision over then No. 22 Indiana. Louisville got as high as No. 6 in the national rankings before dropping to 11th with their loss to the Razorbacks.

Memphis at Louisville Preview

The Memphis Tigers and Louisville Cardinals will play for the first time since 2017 when they square off on Saturday, December 13, 2025 at the KFC Yum! Center in Louisville, KY. Tipoff is slated for 3:30 p.m. ET with the game televised on ESPN.

Public Betting Odds Factors

After a sluggish start that saw them lose four games in a row, including a close setback to No. 1 ranked Purdue and a 1-point defeat on a last-second buzzer-beater from Wake Forest, the Tigers got back to .500 winning their last three games.

Memphis has been competitive in every game except for its loss to UNLV last month. Closing as a 9.5-point favorite the Tigers had issues with their accuracy and committed 18 turnovers in the 92-78 defeat.

The Tigers are one of the most profitable teams in college hoops earning payouts in 7 of their 8 games including the last 5.

Dug McDaniel leads the team averaging 13.9 points reaching double figures in all but one game so far. He also dishes out 6.4 assists per game leading an offense that averages 76 points per game.

Louisville is also an attractive option at the betting window with four payouts in its last five games while going 6-3 against the college basketball odds overall. The Cardinals have enjoyed success at home winning all 6 games and going 4-2 ATS.

Offense has fueled the Cardinals success scoring at least 80 points in eight of their nine games and reaching triple-digits four times. A balanced attack with four players averaging in double figures makes them tough to defend.

The Cards can score points in bunches with the help of the 3-pointer. They average 12.7 made triples a game shooting 36 percent from distance.

Memphis at Louisville Predictions

Louisville has been a complete team in the early season ranking 10th nationally in scoring and boasting the 7th best scoring margin. Five players average more than 9.0 points led by Ryan Conwell, who drops almost 20 a game while shooting 42 percent from deep.

The Cardinals play defense almost as well as they score the basketball. They held five opponents to 70 points or less and throttled Indiana’s high powered attack in their most recent victory. It’ll be hard for Memphis to overcome that

Memphis at Louisville Betting Tips

Both teams have been excellent picks against the college basketball betting line this season. The Tigers have seven payouts in eight games while Louisville is 6-3 ATS with covers in its last two home games when playing against a steep line.

Memphis hasn’t won a road game or neutral site contest this season going 0-3 SU. They were able to stay within the spread in all three, though.

The UNDER is 4-1 in Memphis’ last five games and the Tigers are 4-0 ATS when getting points on the closing line.

Memphis at Louisville Head to Head and Key Stats

The programs played as members of several different conferences over the years with Louisville winning 54 of the 90 all-time meetings.

The last matchup took place in 2017 with Louisville ending a 2-game slide with an 81-72 victory. The Cards were a 12-point dog in that outing making it three straight outings the team getting points won outright.