Louisville at Tennessee Odds | NCAAB Betting Preview

The Tennessee Volunteers lost 8 games all last season making it as far as the Elite Eight in the NCAA Tournament. They will look to end a 3-game losing streak when hosting the Louisville Cardinals in an ACC/SEC matchup.

Following their first and so far only loss of the season the Cardinals rebounded with consecutive wins over quality opponents Memphis and Indiana, getting payouts in both games. With four players averaging more than 10 points per game, Louisville has a potent offense that’s scored more than 100 points four times.

Louisville at Tennessee Preview

Teams expected to compete for their respective conference title battle in a non-conference setting when the 1-loss Louisville Cardinals visit the Tennessee Volunteers. The game is scheduled for Tuesday, December 16, 2025 at the Food City Center in Knoxville, TN at 7 p.m. ET. ESPN provides television coverage.

Public Betting Odds Factors

The Vols have had a hard time closing teams out during its current losing streak. They had the lead at halftime in two of the three matchups but were outscored by a total of 27 points over the final 20 minutes.

Though only two of their last four opponents were nationally ranked at the time of the game, the Vols had a difficult stretch losing to annual powerhouse programs Kansas and Syracuse. The Jayhawks have since reentered the top 25.

Tennessee’s current skid started after they beat then No. 3 Houston before Thanksgiving in a rematch of last season’s NCAA Tournament quarterfinal contest. The Vols avenged that loss winning 76-73.

In all three games during their current losing streak the Vols closed as the favorite in college basketball odds and they are 2-6 ATS in their last eight outings.

Louisville has been a gold mine at the betting window with five payouts in its last six games and going 7-3 against the spread overall. Their only loss came on the road failing to cover the 2.5-point spread against Arkansas on Dec. 3.

The Cardinals average 93.8 points per game, 10th best in the country, with a high-volume of 3-pointers. They attempt 35.2 triples a game, 4th most, and make the third most with 12.7. They were 18 of 35 from distance in a 99-73 win over Memphis last game.

Louisville at Tennessee Predictions

The Cardinals have had success in all aspects of the game making them a tough opponent. They’ve scored at least 80 points in all but one game this season and five players average more than 9.5 points, led by Ryan Conwell at 19.4. As a team they shoot 37.5 percent from deep with Conwell knocking down 42 percent of his triples.

Louisville also boasts a defense that allows just 67.6 points per game for the 6th best scoring margin in the country. The Cards have gone OVER the total in their last 3 games with the number higher than 160.

The Vols are strong defensively holding 7 opponents to fewer than 70 points and allowing just 66 points per game, but the offense struggled in losses to Syracuse and Illinois scoring no more than 62 points.

Louisville at Tennessee Betting Tips

Not only have the Cardinals been winning on the court, they've been one of the more profitable teams at the betting window with two straight payouts and winners against the college basketball odds in five of their last six games.

Louisville has gone OVER the closing total in its last 3 games and in 6 of the last 9 outings.

The Vols have gotten little production from leading scorers JaKobi Gillespie and Nick Ament the last few games. Between them they average nearly 34 points a game but combined for just 24 points on 10 of 34 shooting in a loss to Illinois.

Tennessee has failed to cover in its last 3 games and is 2-6 ATS in its last 8 games.

The Vols are 5-0 SU at home this season but have only one payout in those games, covering the 27-point spread in a 95-56 win over Northern Kentucky in early November.