Following a promising 4-0 start, the Louisville Cardinals were upset at home against the rising Virginia Cavaliers. That loss was a shocker for a team that is aspiring to the ACC championship.
Since then, head coach Jeff Brohm has had two weeks to prepare The Ville for its biggest game of the season. Louisville will hit the road to take on the Miami-FL Hurricanes, who are coming off a bye week, too.
Miami has national championship aspirations, but can’t afford to look past the Cardinals. Louisville will arrive with focus, ability, and determination.
Miami is one of the best looking teams in the country. But Louisville has a good defense and passing attack that may keep them within the big college football odds number.
Louisville at Miami-FL Preview
The Miami Hurricanes will host the Louisville Cardinals at Hard Rock Stadium in Miami Gardens, FL, on Friday, October 17, 2025, at 7 p.m. ET. ESPN or ESPN2 will cover the game.
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Public Betting Odds Factors
- The Hurricanes have long been a popular college football betting brand.
- Miami is getting more business than usual this year because of its powerful start.
- Gamblers should closely evaluate the price and value of the public sector’s favorite Hurricanes.
- Louisville is a quality program, but not one that draws a lot of casual sector support.
- A prime time ESPN Network matchup from Miami means extra wagering action and TV eyeballs.
Louisville at Miami-FL Predictions
Handicapping Factors to Consider
- Louisville has one of the worst rushing attacks in the nation.
- Because they can’t run effectively, the Cardinals have red zone issues.
- Louisville has a problem with turning the ball over.
- The Cardinals have been a weak wagering value despite straight-up success.
- Miami has one of the best defenses in college football.
- The Hurricanes have limited turnovers this season.
- Miami has shown reliable betting value this season.
- However, in this situation, the Hurricanes are overpriced with the betting lines.
- Louisville has enough passing and defense to stay within the number at the very least.
Louisville at Miami-FL Prime Best Bet: Louisville Cardinals
Louisville at Miami-FL Betting Tips
Louisville Cardinals
- The Louisville Cardinals have national metrics of 62nd for total offense, 21st for passing, 113th for rushing, 29th for scoring, and 82nd for fewest turnovers committed.
- Louisville ranks 12th for total defense, 8th vs. the pass, 30 vs. the rush, 47th for fewest points allowed, and 30th for takeaways.
- Louisville is coming off a bye week.
- Last game, the Cardinals lost 30-27 against the Virginia Cavaliers as 6.5-point home
Miami-FL Hurricanes
- The Miami Hurricanes have national metrics of 42nd for total offense, 40th for passing, 62nd for rushing, 35th for scoring offense, and 7th for fewest turnovers committed.
- Miami ranks 16th for total defense, 35th vs. the pass, 13th vs. the rush, 9th for fewest points allowed, and 51st for takeaways.
- Miami is coming off a bye week.
- Last game, Miami beat the Florida State Seminoles 28-22 as 4-point road favorites.
- The Hurricanes and Seminoles went under the total of 54.5.
- Miami is 5-0 straight up, 4-1 against the spread, and 2-3 under the total.
Louisville at Miami-FL Head-to-Head and Key Stats
- Louisville has struggled to show value on the road.
- The Cardinals have only four payouts in their most recent 12 games.
- Seven of Louisville’s last nine away games went over the total.
- Miami has been a strong home betting value.
- The Hurricanes got the cash in five of their most recent six home games.
- Four of Miami’s most recent seven home games went under the total.
- In the series between Louisville and Miami-FL, the Hurricanes covered the spread in three of the most recent four meetings.
- The Cardinals and Hurricanes have gone over the total in their last four games.
- Specifically in Miami, the Cardinals got the money in two of their most recent three matchups.
- The Canes and Cards went over the total in three straight games at Miami.
