College Football Week 12 Betting Picks & Odds

With pressure mounting and the importance of the games more pronounced, Week 12 offers plenty of opportunity. Teams will either be looking for Helmet Sticker wins against the biggest brands in college football or for style points to improve College Football Playoff seeding priority.

The College Football Playoff-bound Indiana Hoosiers escaped death at Penn State with a thrilling win on Saturday and will host the outclassed Wisconsin Badgers at Noon ET on the Big Ten Network with a Noon ET kickoff.

The Maryland Terrapins, wrapping up a lost season, will visit the hard-working and well-coached Illinois Fighting Illini with a kickoff at 3:30 p.m. ET and coverage on FS1.

The UCLA Bruins face a tall task at the Horseshoe against the defending national champion Ohio State Buckeyes. This matchup is the NBC prime-time game of the week, with a 7:30 p.m. ET kickoff.

The Ole Miss Rebels are in line for the CFP but have a potentially dangerous home game against the Florida Gators, who were annihilated at Kentucky last week but still have a talented roster. Kickoff time is 7 p.m. ET with coverage on ESPN.

And in the ACC, the inconsistent Miami-FL Hurricanes host the tough NC State Wolfpack at 3:30 p.m. ET on ESPN.

Notable CFB Week 12 Odds

Michigan (-9.5) is an intriguing price on the road against Northwestern. Both teams are tough and conservative, but Michigan will have the majority of the fans and the more talented roster in this Big Ten matchup at iconic Wrigley Field.
Texas (+6.5) is an interesting line on the road against the Georgia Bulldogs. After a sluggish start, quarterback Arch Manning and the Longhorns are finding their groove. But Georgia could be the best team in the country. The Longhorns have momentum and are getting a good price.
Oklahoma (+6.5) catches attention for its road game against the Alabama Crimson Tide, who are also in the mix for being the nation’s best team. Oklahoma’s win at Tennessee has caught the attention of gamblers. This could be a letdown spot for Bama after a rivalry win over LSU.

CFB Week 12 Predictions

Indiana -30.5 vs. Wisconsin – The Hoosiers have been rampaging towards the College Football Playoff and holding good value on the way. Wisconsin is one of the worst Power Four programs in the country. However, the Badgers upset the Washington Huskies last week. It's doubtful that Wisconsin can put together two straight winning performances.
Ohio State -30.5 vs. UCLA – Last week against visiting Nebraska, UCLA was dominated in a 28-21 loss that was not as close as the score indicated.
Now comes a difficult road assignment at the Shoe against the Ohio State Buckeyes, who have been bossing the cashier’s cage in 2025.
Illinois -14.5 vs. Maryland – The Maryland Terrapins are playing out the string and coming off an ugly loss to mediocre Rutgers. Illinois fights hard for head coach Bret Bielema and is coming off a bye week after blowing out Rutgers in its last game.
Ole Miss -13.5 vs. Florida – Head coach Lane Kiffin and his Ole Miss Rebels had better not look past a talented Florida team that nearly upset Georgia two weeks ago. However, Ole Miss has been a much more effective value in 2025. Florida is a talented team, but last week’s stink bomb at Kentucky is the ultimate tell that the Gators have likely packed it in.
NC State +14.5 at Miami – Miami seemed to be on the way to the CFP before flopping with alarming losses to Louisville and SMU. Last week, The U routed an outclassed Syracuse team in a game that could have been worse than it was. Now comes the tough NC State Wolfpack to Hard Rock Stadium. The Wolfpack lacks Miami's resources and talent but has better fundamentals and mental toughness. This is the type of matchup Miami often struggles to close out.