Cavaliers at 76ers: NBA Odds, Total & Best Bets

The Cavs haven’t had the same early season success they enjoyed last year and have struggled to stay above .500. They have won 5 of 7 games following Saturday’s win over Minnesota after going 2-5 in their previous 7 contests and are currently 22-18.

The race in the Eastern Conference is tight as we get to the halfway mark in the season, and the 76ers are in the thick of things. They had won 5 of their last 6 games until Sunday’s overtime loss at Toronto. Eight teams in the East enter the week with between 20 and 25 wins with Philly and Cleveland among them.

Cavaliers at 76ers Preview

The first of two straight games between Eastern Conference contenders the Cleveland Cavaliers and Philadelphia 76ers takes place on Wednesday, January 14, 2026, at 7 p.m. ET from Xfinity Mobile Arena in Philadelphia. ESPN will air the game live.

Public Betting Odds Factors

The Cavaliers might be pacing themselves after their torrid start last season led them to the No. 1 seed in the East. With enormous expectations entering the playoffs, the Cavs were upended by Indiana in the second round.

Unless they really choke in the second half of the season the Cavs should again qualify for the playoffs. They would like to avoid the play-in tournament, though, and currently find themselves as the No. 7 seed. They enter the week just 7 games behind Detroit with five teams between them in the standings.

The makeup of the team remains largely the same leading me to believe the Cavs are more concerned about a long playoff run rather than regular season success. They won 64 games a season ago and were 34-6 through 40 games. After Saturday’s win over Minnesota the Cavs are 22-18.

The Cavs boast the highest scoring team in the East and third-highest overall averaging 119.9 points per game. For the third time this season they scored more than 140 points in a regulation game in the 146-134 win over Minnesota, going OVER the total on the NBA spread in a second straight contest.

With Joel Embiid, Paul George and Tyrese Maxey shuffling in and out of the lineup the Sixers have managed to keep pace in the East. They won 5 of 6 games going 5-1 against the NBA betting odds before losing to Toronto without Embiid or George in the lineup.

With Embiid and George combining to play in just 39 games, Maxey has picked up the slack averaging 30.9 points, third-most in the NBA.

Cavaliers at 76ers Predictions

A recent win over Washington showed just how lethal the 76ers can be when their projected starting lineup is intact. Embiid and George had big games in the 131-110 rout with each scoring more than 20 points. Maxey had 22 points and 8 assists.

The former MVP Embiid has dealt with injuries his entire career and doesn’t play in back to back games, but he’s put up 25.3 points and 7.1 rebounds per game. During a recent stretch with Embiid playing in six consecutive games, the Sixers went 4-1 SU and ATS with their lone setback to Denver by a point in overtime.

Cavaliers at 76ers Betting Tips

Though they earned a payout covering the 2.5-point spread in a 146-134 win over Minnesota on Saturday, the Cavs have been a money pit this season with the worst cover percentage in the NBA. They have payouts in just 32.5 percent of their games.

On the other side Philly has been one of the best bets in the NBA going 22-15 against the NBA betting line, the 2nd best cover percentage in the league.

The Sixers have played OVER the closing total in 8 of their last 11 games.

Cavaliers at 76ers Head to Head and Key Stats

The teams met for the first time this season in November with Donovan Mitchell scoring 46 points in Cleveland’s 132-121 victory, the Cavs’ fourth in the last 5 meetings.

Playing without Embiid and George in that contest, the Sixers were able to stay within the 16.5 point spread to earn their second straight payout and sixth in the last 7 meetings.