Bills at Texans Picks: Odds & Betting Tips

Since the 2019 NFL season, the Buffalo Bills have made the playoffs every time. However, the Super Bowl has proven elusive.

Since losing their fourth consecutive Super Bowl in the 1993 season, the Bills have been on the outside looking in.

But Buffalo is good enough to finally make it if the Kansas City Chiefs will just get out of the way.

This week, the Bills have a challenging road game against the Houston Texans.

Houston has not been in sync most of the year and is facing an increasingly difficult AFC South Division.

Certainly, the quarterbacking of Buffalo’s Josh Allen is must-see viewing.

On the other hand, Houston’s CJ Stroud is questionable due to concussion protocol.

These two perennial contenders playing the only Thursday night NFL game will be a major draw at the NFL betting window

Bills at Texans Preview

On Thursday, November 20, 2025, the Houston Texans will host the Buffalo Bills at NRG Stadium in Houston, TX. Kickoff is at 8:15 p.m. ET, with television coverage on Prime Video.

Public Betting Odds Factors

• Houston has been a poor betting value this year, and Stroud has had recent concussion issues.

• In this matchup, Buffalo is the much more popular brand as a regular Super Bowl contender.

• The Bills have the credibility of being a team that has played for high stakes over the past several years.

• Of course, the Bills will get the more favorable road team price.

Bills at Texans Predictions

Handicapping Factors to Consider 

• Although the Texans are struggling to hold value, they have been a highly profitable team at home.

• As mentioned earlier, the Texans have provided good value at home and against the Bills.

• This series trends strongly under the total at Houston.

• Finally, Buffalo’s brand popularity will keep the Houston price advantageous.

• If Stroud is out, the price on Buffalo will only increase more.

Bills at Texans Prime Best Bet: Houston Texans 

Bills at Texans Betting Tips

• Buffalo opened as a 4.5-point favorite and a -235 moneyline chalk.

• Houston opened as a 4.5-point dog and a +194 moneyline dog.
• The Bills and Texans opened with a total of 43.5.

Buffalo Bills 

• Buffalo has covered three out of its most recent four games.

• Buffalo went under the total in four of its last six matchups.

• Buffalo is in 2^nd place in the AFC East Division.

• Buffalo ranks 4^th for total offense, 8^th for passing, 2^nd for rushing, 5^th for scoring, and 18^th for fewest turnovers committed.

• Buffalo ranks 12^th for total defense, 2^nd vs. the pass, 30^th vs. the rush, 14^th for fewest points allowed, and 16^th for takeaways.

• Last game, the Buffalo Bills won 44-32 against the Tampa Bay Buccaneers as 6-point home favorites.

• The game went over the total of 46.5.

• Buffalo is 7-3 straight up, 5-5 against the spread, and 5-5 over/under the total.

Houston Texans 

• Houston has covered two out of its most recent five games.

• Houston went over the total in one of its last four matchups.

• Houston is in 3^rd place in the AFC South Division.

• Houston ranks 20^th for total offense, 16^th for passing, 23^rd for rushing, 22^nd for scoring, and 9^th for fewest turnovers committed.

• Houston ranks 1^st for total defense, 3^rd vs. the pass, 3^rd vs. the rush, 1^st for fewest points allowed, and 6^th for takeaways.

• Last game, the Houston Texans won 16-13 against the Tennessee Titans as 5.5-point road favorites.

• The game went under the total of 37.

• Houston is 5-5 straight up, 4-6 against the spread, and 3-6-1 over/under the total.

Bills at Texans Head-to-Head and Key Stats

• In the Series between the Bills and Texans, Buffalo covered the spread in three of the last five meetings.

• The Bills and Texans went under the total in seven of their last eight games.

• Specifically, in Houston, the Texans covered the spread in four of their last five games against the Bills.

• The Bills and Texans went under the total in their last five meetings in Houston.

• Buffalo has covered the spread in six of its last 11 away games.

• The Bills went under the total in three of their most recent four road tilts.

• Houston lost only five of its last 16 home games against the spread.

• The Texans went over the total in only five of their most recent 20 home tilts.