49ers at Seahawks Odds & Best Bets | NFL Divisional

For the third time this season and second time in three weeks the San Francisco 49ers and Seattle Seahawks will square off in a Divisional Round matchup with a trip to the NFC Championship game on the line. Seattle secured the No. 1 seed in the NFC with a Week 18 win over the Niners and is the biggest favorite on the early board. The game kicks at 8 p.m. ET on Saturday, Jan. 17 from Lumen Field in Seattle and will air on FOX.

49ers at Seahawks Preview

Already shorthanded on defense the Niners sustained a blow when George Kittle sustained an Achilles injury last week. The Niners managed to survive and beat the defending champion Eagles, 23-19, behind a strong defensive game. Kittle was the second-leading receiver with 57 catches during the regular year and the offense will be impacted.

Once Brock Purdy returned from injury the offense clicked, averaging nearly 36 points during a 6-game winning streak. They were silenced by Seattle’s D in Week 18 scoring just 3 points and managing 173 yards. And the loss of Kittle will impact their ability to score points. Demarcus Robinson stepped up last week with 6 catches for 111 yards and a TD.

Including last week’s win when catching 5.5-points on the NFL spread, the Niners are 3-4 SU and ATS when playing as an underdog.
We’re likely to see more of Christian McCaffrey, who had 114 scrimmage yards and 2 TD catches last week. CMac was 2nd in the NFL during the season with 2,126 scrimmage yards.
Purdy tossed a pair of interceptions to the Eagles and has at least one in 4 straight games and 12 total for the season.
Impacted by injuries to the D line during the season, the Niners were last in the NFL with just 20 sacks.

Seattle might be the most balanced team remaining. The defense shut down the Niners in Week 18 and finished the year No. 1 in fewest points allowed. In two games against SF the unit allowed a total of 20 points and an average of fewer than 280 yards. They held 5 of their last 6 opponents to 16 points or less winning their last 7 games.

The Seahawks aren’t without their flaws. Sam Darnold threw for more than 4,000 yards, but his 14 interceptions were third-most in the NFL. And the Seahawks turned the ball over 28 times, second most in the NFL. Two of those giveaways took place in the season opener, a 17-13 loss to the Niners.

Seattle allowed just 5.88 yards per play, 6th best in the NFL.
Darnold was sacked just 27 times during the season, one of the lowest figures among starting QBs.
The Seahawks won their last 5 home games allowing an average of 18.8 points per game and went 6-2 overall at home.
Kenneth Walker and Zach Charbonnet combined to rush for 1757 yards for the 10th best run game.

49ers at Seahawks Predictions

Given the recent history between the clubs and with a trip to the NFC Championship at stake, there’s a good chance points will be tough to come by. In their two regular season meetings the teams combined to score 46 points, an average of 23 per game making the UNDER look like a safe bet.

49ers at Seahawks Betting Tips

Seattle is listed as a 7-point favorite on the early line.
The Seahawks have had payouts in 9 of their last 12 games and they were one of the most profitable teams going 12-5 against the NFL betting line.
Moneyline odds have Seattle at -372 and the Niners at +310.
Including their Wild Card win the Niners have 6 payouts in their last 8 games.
SF is 8-2 SU and ATS overall on the road this season.
The total surfaced at 45.

49ers at Seahawks Head to Head and Key Stats

Seattle’s 20-17 win last season ended a 6-game Niners win streak in the series.
The road team has won each of the last 4 matchups.
The teams split the 2025 season series scoring a combined total of 46 points.
This will be the 3rd playoff meeting between the teams with each winning at home in the first 2.
Seattle has won 32 of the 56 all-time matchups but is just 2-7 in the last 9.