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2025 US Open: Tennis Odds, Predictions & Betting Tips

A Grand Slam tennis event is a truly special occasion. Similar to golf’s major tournaments, the Grand Slams are made up of the four most prestigious tournaments each year. However, there is a notable difference between the US Open and the other three Grand Slams.

The US Open Championships are the most competitive of any Grand Slam event. The US Open is known for upsets, shockers, tradition, and rituals. Most players would trade all their wins for one US Open championship.

The US Open attracts celebrities and dignitaries like few other events. Check out this guide so you know all about the available tennis betting options.

2025 US Open Tennis Preview

The US Open Tennis Championships will run from August 24 through September 7, 2025, at the UTSA Billie Jean King National Tennis Center in New York City, New York. Television coverage is on ABC, ESPN, ESPN2, and ESPNews.

The US Open, as one of the Grand Slam events in tennis, guarantees that the best players in the world will be on hand to participate. Players such as Daniil Medvedev and Coco Gauff made their names at the US Open.

Gambling interest is massive, especially in the United States, where the event draws presidents and A-list celebrities to the grandstands.

2025 US Open Tennis Predictions

On this occasion, on the men’s side, Carlos Alcaraz makes the most sense with the US Open. He has an unimpeachable record in recent Grand Slam events, emerging as the new dominant men’s player.

On the Ladies’ side, Coco Gauff offers incredible value and better form than other, more expensive choices. Of course, Gauff made her fame at the US Open.

2025 US Open Championships 2025 Prime Best Bets: Carlos Alcaraz and Coco Gauff 

2025 US Open Tennis Betting Tips

2025 US Open Gentlemen’s Singles Championship Prime Odds:

  • Jannik Sinner +110
  • Carlos Alcaraz +185
  • Novak Djokovic +1200
  • Jack Draper +1400
  • Alexander Zverev +1600
  • Daniil Medvedev +2500
  • Ben Shelton +2000
  • Taylor Fritz +2000
  • All Other Players +5000 or Higher

2025 US Open Ladies’ Singles Championship Prime Odds:

  • Aryna Sabalenka +250
  • Iga Swiatek +330
  • Coco Gauff +600
  • Mirra Andreeva +900
  • Elena Rybakina +1000
  • Madison Keys +1800
  • All Other Players +2000 or Higher

The odds show a changing of the guard on the men’s side as Novak Djokovic is on the decline and near the end of his career. On the women’s side, the tremendous parity shows in the betting lines, especially in comparison to the men, which gamblers consider to be a 2-man battle.

Women’s tennis continues to provide a great handicapping challenge with several legitimate potential winners. The US Open has a history of surprise winners and upsets, so gamblers should be prudent about getting top value.

2025 US Open Tennis Head to Head and Key Stats

2025 US Open Men's Singles Top Contenders 

  • Jannik Sinner+110

First in the ATP rankings is Jannik Sinner, who has won Grand Slam titles at the Australian Open (2024 and 2025), Wimbledon (2025), and the 2024 US Open.

So far this year, Sinner has a record of 26-3 with two championships. His career record is 289-83 with 20 titles.

  • Carlos Alcaraz +185

Second in the ATP standings is Carlos Alcaraz. His record in 2025 is 48-6 with five titles. In his career, Alcaraz is 257-62 with 21 titles. Alcaraz is collecting Grand Slam championships at a rapid rate.

To show, he won the French Open in 2024 and 2025, the Wimbledon Championship in 2023 and 2024, and the US Open in 2022.

  • Novak Djokovic +1200

Now, at age 38, Novak Djokovic remains a respected megabrand with the casual sector. Djokovic is 7th in the ATP rankings with a record of 26-9 and one title. His career record is 1150-231 with 100 titles.

Djokovic owns 24 Grand Slam titles and a career Grand Slam. However, his last Grand Slam title was at the 2023 US Open. His last Wimbledon title was in 2022.

  • Jack Draper +1400

Overall, Jack Draper is ranked 5th with a record of 29-9 and one title. His career record is 108-60 with three titles. Draper is still in pursuit of his first Grand Slam title.

As a native of London, England, a win across the pond at the US Open would be apropos.

2025 US Open Ladies’ Singles Top Contenders 

  • Aryna Sabalenka +250

First in the WTA rankings is Aryna Sabalenka. So far this year, Sabalenka is 47-9 with three titles. Her career record is 463-197 with 20 titles.

Sabalenka has two Grand Slam championships. She won the Australian Open in 2021, and in 2019, she took the US Open.

  • Iga Swiatek +500

Third in the WTA rankings in 2025, Iga Swiatek is 34-12 with 1 title. Her career record is 386-87 with 23 titles. Swiatek is a popular brand among the masses, which is why it is more expensive than it should be.

She is a 4-time French Open champion (2020, 2022, 2023, and 2024). Also, Swiatek won the US Open in 2022. Her best finish at Wimbledon was a win in 2025.

  • Elena Rybakina +500

Of course, Elena Rybakina is best known for winning the 2022 US Open championship. That was her only career Grand Slam win.

So far in 2025, Rybakina is 37-15 with one title and a ranking of 10th. Her career record is 368-158 with nine titles.

  • Coco Gauff +900

Coco Gauff is 33-11 with one title this year. She is ranked 2nd in the WTA standings. Her career record is 262-110 with ten singles titles.

Gauff was the winner of the 2025 French Open, and she won the 2023 US Open, emerging as a world sensation. Gauff burst on the international scene with her first Grand Slam win at the US Open.

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